COVID vaccines still work against mutant, researchers find

New research from France adds to evidence that widely used COVID-19 vaccines still offer strong protection against a coronavirus mutant that is spreading rapidly around the world and now is the most prevalent variant in the US.

The Delta variant is surging through populations with low vaccination rates. On Thursday, Dr. Rochelle Walensky, director of the US Centers for Disease Control and Prevention (CDC), said that’s leading to “two truths” – highly immunised swathes of America are getting back to normal, while hospitalisations are rising in other places.

“This rapid rise is troubling,” she said: A few weeks ago the Delta variant accounted for just over a quarter of new US cases, but it now accounts for just over 50 percent – and in some places, such as parts of the Midwest, as much as 80 percent.

Researchers from France’s Pasteur Institute reported new evidence on Thursday that full vaccination is critical.

In laboratory tests, blood from several dozen people given their first dose of the Pfizer or AstraZeneca vaccines “barely inhibited” the Delta variant, the team reported in the journal Nature. But weeks after getting their second dose, nearly all had what researchers deemed an immune boost strong enough to neutralise the Delta variant – even if it was a little less potent than against earlier versions of the virus.

The French researchers also tested unvaccinated people who had survived a bout of the coronavirus and found their antibodies were fourfold less potent against the new mutant. But a single vaccine dose dramatically boosted their antibody levels – sparking cross-protection against the Delta variant and two other mutants, the study found. That supports public health recommendations that COVID-19 survivors get vaccinated rather than relying on natural immunity.

The lab experiments add to real-world data that the Delta variant’s mutations aren’t evading the vaccines most widely used in Western countries, but underscore that it’s crucial to get more of the world immunised before the virus evolves even more.

Researchers in Britain found that two doses of the Pfizer vaccine, for example, are 96 percent protective against hospitalisation with the Delta variant and 88 percent effective against symptomatic infection. That finding was echoed last weekend by Canadian researchers, while a report from Israel suggested protection against mild Delta infection may have dipped lower, to 64 percent.

Whether the fully vaccinated still need to wear masks in places where the Delta variant is surging is a growing question. In the US, the CDC maintains that fully vaccinated people don’t need to. Even before the Delta variant came along, the vaccines weren’t perfect, but the best evidence suggests that if vaccinated people nonetheless get the coronavirus, they’ll have much milder cases.

“Let me emphasise, if you were vaccinated, you have a very high degree of protection,” Dr Anthony Fauci, the US government’s top infectious disease expert, said on Thursday.

In the US, case rates have been rising for weeks and the rate of hospitalisations has started to tick up, rising seven percent from the previous seven-day average, Walensky told reporters on Thursday. However, deaths remain down on average, which some experts believe is at least partly due to high vaccination rates in people 65 and older — who are among the most susceptible to severe disease.

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